Malocclusion impairs cognitive behavior via AgRP signaling in adolescent mice.

ABSTRACT:

Introduction

Occlusal disharmony induced by deteriorating oral health conditions, such as tooth loss and decreased masticatory muscle due to sarcopenia, is one of the causes of cognitive impairment. Chewing is an essential oral function for maintaining cognitive function not only in the elderly but also in young people. Malocclusion is an occlusal disharmony that commonly occurs in children. The connection between a decline in cognitive function and malocclusion in children has been shown with chronic mouth breathing, obstructive sleep apnea syndrome, and thumb/digit sucking habits. However, the mechanism of malocclusion-induced cognitive decline is not fully understood. We recently reported an association between feeding-related neuropeptides and cognitive decline in adolescent mi

SUBMITTER: Kusumoto J 

PROVIDER: S-EPMC10164942 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature