MiRNome of Child A hepatocellular carcinoma in Egyptian patients.

ABSTRACT:

Introduction

Hepatocellular carcinoma (HCC) has different etiologies that contribute to its heterogeneity. In regards to the number of HCC patients, Egypt ranks third in Africa and fifteenth worldwide. Despite significant advancements in HCC diagnosis and treatment, the precise biology of the tumor is still not fully understood, which has a negative impact on patient outcomes.

Methods

Advances in next-generation sequencing (NGS) have increased our knowledge of the molecular complexity of HCC.

Results & discussion

In this research, 16 HCC and 6 tumor adjacent tissues (control) of Child A Egyptian patients were successfully profiled for the expression profile of miRNAs by NGS. Forty-one differentially expressed miRNAs (DEMs) were found by differential expression analysi

SUBMITTER: El-Shqnqery HE 

PROVIDER: S-EPMC10164962 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature