Resveratrol alleviates lipopolysaccharide-induced liver injury by inducing SIRT1/P62-mediated mitophagy in gibel carp (Carassius gibelio).

ABSTRACT:

Introduction

Resveratrol (RES) is a polyphenol organic compound with antioxidant and anti-inflammatory properties. This study aimed to determine whether and how RES can alleviate liver injury in lipopolysaccharide (LPS)-induced gibel carp.

Methods

Gibel carp were fed a diet with or without RES and were cultured for 8 weeks, followed by LPS injection.

Results and discussion

The results suggested that RES attenuated the resulting oxidative stress and inflammation by activating the Nrf2/Keap1 pathway and inhibiting the NF-κB pathway, as confirmed by changes in oxidative stress, inflammation-related gene expression, and antioxidant enzyme activity. Furthermore, RES cleared damaged mitochondria and enhanced mitochondrial biogenesis to mitigate reactive oxygen species (ROS)

SUBMITTER: Wu L 

PROVIDER: S-EPMC10164966 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature