Staphylococcus aureus increases Prostaglandin E₂ secretion in cow neutrophils by activating TLR2, TLR4, and NLRP3 inflammasome signaling pathways.

ABSTRACT:

Introduction

In clinical settings, dairy cows are often attacked by pathogenic bacteria after delivery, especially Staphylococcus aureus (S. aureus). Neutrophils have long been regarded as essential for host defense against S. aureus. Prostaglandin E₂ (PGE₂) can additionally be used as an inflammatory mediator in pathological conditions to promote the repair of inflammatory injuries. However, whether S. aureus can promote the accumulation of PGE₂ after the infection of neutrophils in cows and its mechanism remain unclear. Lipoprotein is an important immune bioactive ingredient of S. aureus.

Methods

In this study, the changes in neutrophils were monitored in dairy cows infected with wild-type S. aureus

SUBMITTER: Zhang K 

PROVIDER: S-EPMC10165004 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature