Physiological fibrin hydrogel modulates immune cells and molecules and accelerates mouse skin wound healing.

ABSTRACT:

Introduction

Wound healing is a complex process to restore homeostasis after injury and insufficient skin wound healing is a considerable problem in medicine. Whereas many attempts of regenerative medicine have been made for wound healing with growth factors and cell therapies, simple pharmacological and immunological studies are lagging behind. We investigated how fibrin hydrogels modulate immune cells and molecules in skin wound healing in mice.

Methods

Physiological fibrin hydrogels (3.5 mg/mL fibrinogen) were generated, biophysically analyzed for stiffness and protein contents and were structurally studied by scanning electron microscopy. Physiological fibrin hydrogels were applied to full thickness skin wounds and, after 3 days, cells and molecules in wound tissues were

SUBMITTER: Pereira RVS 

PROVIDER: S-EPMC10165074 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature