Probiotics fortify intestinal barrier function: a systematic review and meta-analysis of randomized trials.

ABSTRACT:

Background

Probiotics play a vital role in treating immune and inflammatory diseases by improving intestinal barrier function; however, a comprehensive evaluation is missing. The present study aimed to explore the impact of probiotics on the intestinal barrier and related immune function, inflammation, and microbiota composition. A systematic review and meta-analyses were conducted.

Methods

Four major databases (PubMed, Science Citation Index Expanded, CENTRAL, and Embase) were thoroughly searched. Weighted mean differences were calculated for continuous outcomes with corresponding 95% confidence intervals (CIs), heterogeneity among studies was evaluated utilizing I2 statistic (Chi-Square test), and data were pooled using random effects meta-analyses.

Results

Meta-ana

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC10165082 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature