Cortical hierarchy disorganization in major depressive disorder and its association with suicidality.

ABSTRACT:

Objectives

To explore the suicide risk-specific disruption of cortical hierarchy in major depressive disorder (MDD) patients with diverse suicide risks.

Methods

Ninety-two MDD patients with diverse suicide risks and 38 matched controls underwent resting-state functional MRI. Connectome gradient analysis and stepwise functional connectivity (SFC) analysis were used to characterize the suicide risk-specific alterations of cortical hierarchy in MDD patients.

Results

Relative to controls, patients with suicide attempts (SA) had a prominent compression from the sensorimotor system; patients with suicide ideations (SI) had a prominent compression from the higher-level systems; non-suicide patients had a compression from both the sensorimotor system and higher-level systems,

SUBMITTER: Shiwei L 

PROVIDER: S-EPMC10165114 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature