Dataset Information

Incidence of Bone Metastases and Skeletal-Related Events in Patients With EGFR-Mutated NSCLC Treated With Osimertinib.

ABSTRACT:

Introduction

Bone metastases are frequent in patients with EGFR-mutated (EGFR+) NSCLC. Skeletal-related events (SREs) are common in these patients; however, no data on SRE in osimertinib-treated patients are reported. We investigated the development of bone metastases and SREs in patients with EGFR+ NSCLC treated with osimertinib.

Methods

This is a retrospective multicenter cohort study that included patients with metastatic EGFR+ NSCLC who were treated with osimertinib between February 2016 and September 2021. Demographics, bone metastases-related outcomes, SREs, treatment efficacy, and overall survival (OS) were collected.

Results

In total, 250 patients treated with osimertinib (43% first line) were included. Of the patients, 51% had bone metastases at initiation of osimertinib. Furthermore, 16% of the patients with bone metastases used bone-targeted agents. Median follow-up from initiation of osimertinib was 23.4 months (95% confidence interval [CI]: 19.9-26.9 mo). During osimertinib treatment, 10% developed new bone metastases or bone progression. Of the patients with bone metastases, 39% had more than or equal to one SREs: 28% developed first SRE before osimertinib treatment, 1% after, and 11% during. Median OS post-bone metastasis was 30.8 months (95% CI: 21.9-39.7). Median OS after first SRE was 31.1 months (95% CI: 15.8-46.5).

Conclusions

Bone metastases and SREs are frequent before and during treatment with osimertinib in EGFR+ NSCLC. Because of these findings and the long OS post-bone metastases, we advocate prescription of bone-targeted agents in these patients and recommend adding bone-specific end points in clinical trials.

SUBMITTER: Brouns AJWM

PROVIDER: S-EPMC10165134 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Publications

Incidence of Bone Metastases and Skeletal-Related Events in Patients With <i>EGFR</i>-Mutated NSCLC Treated With Osimertinib.

Brouns Anita J W M AJWM van Veelen Ard A Veerman G D Marijn GDM Steendam Christi C Dursun Safiye S van der Leest Cor C Croes Sander S Dingemans Anne-Marie C AC Hendriks Lizza E L LEL

JTO clinical and research reports 20230403 5

<h4>Introduction</h4>Bone metastases are frequent in patients with <i>EGFR</i>-mutated (<i>EGFR+</i>) NSCLC. Skeletal-related events (SREs) are common in these patients; however, no data on SRE in osimertinib-treated patients are reported. We investigated the development of bone metastases and SREs in patients with <i>EGFR+</i> NSCLC treated with osimertinib.<h4>Methods</h4>This is a retrospective multicenter cohort study that included patients with metastatic <i>EGFR+</i> NSCLC who were treated ...[more]

PMID: 37168878

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