Estimated GFR Accuracy When Cystatin C- and Creatinine-Based Estimates Are Discrepant in Older Adults.

ABSTRACT:

Rationale & objective

Serum creatinine and cystatin C are used to estimate glomerular filtration rate, but creatinine-based estimated glomerular filtration rate (eGFRcr), cystatin C-based estimated glomerular filtration rate (eGFRcys), and combined creatinine- and cystatin C-based estimated glomerular filtration rate (eGFRcr-cys) are often divergent, particularly in older adults. We investigated which estimated glomerular filtration rate (eGFR) was more accurate and less biased compared with measured glomerular filtration rate (mGFR).

Study design

A diagnostic test study from the Berlin Initiative Study.

Setting & participants

The study population included 657 individuals aged 70 years or older with iohexol plasma clearance (mGFR) and serum creatinine and cystatin C m

SUBMITTER: Potok OA 

PROVIDER: S-EPMC10165149 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature