A genomic enhancer signature associates with hepatocellular carcinoma prognosis.

ABSTRACT:

Background & aims

Lifestyle and environmental-related exposures are important risk factors for hepatocellular carcinoma (HCC), suggesting that epigenetic dysregulation significantly underpins HCC. We profiled 30 surgically resected tumours and the matched adjacent normal tissues to understand the aberrant epigenetic events associated with HCC.

Methods

We identified tumour differential enhancers and the associated genes by analysing H3K27 acetylation (H3K27ac) chromatin immunoprecipitation sequencing (ChIP-seq) and Hi-C/HiChIP data from the resected tumour samples of 30 patients with early-stage HCC. This epigenome dataset was analysed with previously reported genome and transcriptome data of the overlapping group of patients from the same cohort. We performed patient-specifi

SUBMITTER: Jeon AJ 

PROVIDER: S-EPMC10165154 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature