Use of experimental medicine approaches for the development of novel psychiatric treatments based on orexin receptor modulation.

ABSTRACT: Despite progress in understanding the pathological mechanisms underlying psychiatric disorders, translation from animal models into clinical use remains a significant bottleneck. Preclinical studies have implicated the orexin neuropeptide system as a potential target for psychiatric disorders through its role in regulating emotional, cognitive, and behavioral processes. Clinical studies are investigating orexin modulation in addiction and mood disorders. Here we review performance-outcome measures (POMs) arising from experimental medicine research methods which may show promise as markers of efficacy of orexin receptor modulators in humans. POMs provide objective measures of brain function, complementing patient-reported or clinician-observed symptom evaluation, and aid the translation fro

SUBMITTER: Beckenstrom AC 

PROVIDER: S-EPMC10165155 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature