Distinct and joint effects of low and high levels of Aβ and tau deposition on cortical thickness.

ABSTRACT: Alzheimer's disease (AD) is defined by the presence of Amyloid-β (Aβ),tau, and neurodegeneration (ATN framework) in the human cerebral cortex. Yet, prior studies have suggested that Aβ deposition can be associated with both cortical thinning and thickening. These contradictory results are attributed to small sample sizes, the presence versus absence of tau, and limited detectability in the earliest phase of protein deposition, which may begin in young adulthood and cannot be captured in studies enrolling only older subjects. In this study, we aimed to find the distinct and joint effects of Aβ andtau on neurodegeneration during the progression from normal to abnormal stages of pathologies that remain elusive. We used¹⁸F-MK6240 and ¹⁸F-Florbetaben/¹⁸F-Florbet

SUBMITTER: Hani Hojjati S 

PROVIDER: S-EPMC10165160 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature