Outcomes and predictors of response to fractionated radiotherapy as primary treatment for intracranial meningiomas.

ABSTRACT:

Background

Surgery is the primary treatment for most meningiomas. However, primary fractionated radiotherapy (fRT) remains an option for patients with larger meningiomas in challenging anatomic locations or patients at prohibitively high surgical risk. Outcome prediction for these patients is uncertain and cannot be guided by histopathology without available tumor tissue from surgery. Therefore, we aimed to assess the clinical factors that contribute to treatment failure in a large cohort of meningiomas consecutively treated with fRT as primary therapy, with the goal of identifying predictors of response.

Methods

Patients treated with primary fRT for intracranial meningiomas from 1998 to 2017 were reviewed. Those who received primary surgical resection, radiosurgery, previou

SUBMITTER: Wang JZ 

PROVIDER: S-EPMC10165177 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature