An inventory of crosstalk between ubiquitination and other post-translational modifications in orchestrating cellular processes.

ABSTRACT: Ubiquitination is an important post-translational modification (PTM) that regulates a large spectrum of cellular processes in eukaryotes. Abnormalities in ubiquitin signaling underlie numerous human pathologies including cancer and neurodegeneration. Much progress has been made during the last three decades in understanding how ubiquitin ligases recognize their substrates and how ubiquitination is orchestrated. Several mechanisms of regulation have evolved to prevent promiscuity including the assembly of ubiquitin ligases in multi-protein complexes with dedicated subunits and specific post-translational modifications of these enzymes and their co-factors. Here, we outline another layer of complexity involving the coordinated access of E3 ligases to substrates. We provide an extensive inven

SUBMITTER: Barbour H 

PROVIDER: S-EPMC10165199 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature