Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1.

ABSTRACT:

Background

During the tumourigenesis and development of colorectal cancer (CRC), the inactivation of tumour suppressor genes is closely involved, although detailed molecular mechanisms remain elusive. Accumulating studies, including ours, have demonstrated that basic leucine zipper transcription factor ATF (activating transcription factor)-like 2 (BATF2) is a capable tumour suppressor that localises in the nucleus. However, its different subcellular localisation, potential functions and underlying mechanisms are unclear.

Methods

The translocation of BATF2 and its clinical relevance were detected using CRC samples, cell lines and xenograft nude mice. Candidate BATF2-binding proteins were screened using co-immunoprecipitation, quantitative label-free liquid chromatography-tand

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10165233 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature