Genetic variations in the retrograde endocannabinoid signaling pathway in Chinese patients with major depressive disorder.

ABSTRACT:

Background

The retrograde endocannabinoid (eCB) pathway is closely associated with the etiology of major depressive disorder (MDD) at both pathophysiological and genetic levels. This study aimed to investigate the potential role of genetic mutations in the eCB pathway and underlying mechanisms in Han Chinese patients with MDD.

Methods

A total of 96 drug-naïve patients with first-episode MDD and 62 healthy controls (HCs) were recruited. Whole-exome sequencing was performed to identify the gene mutation profiles in patients with MDD. Results were filtered to focus on low-frequency variants and rare mutations (minor allele frequencies <0.05) related to depressive phenotypes. Enrichment analyses were performed for 146 selected genes to examine the pathways in which the most sign

SUBMITTER: Xu H 

PROVIDER: S-EPMC10165312 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature