Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain.

ABSTRACT: Cognitive decline is a common pathological outcome during aging, with an ill-defined molecular and cellular basis. In recent years, the concept of inflammaging, defined as a low-grade inflammation increasing with age, has emerged. Infiltrating T cells accumulate in the brain with age and may contribute to the amplification of inflammatory cascades and disruptions to the neurogenic niche observed with age. Recently, a small resident population of regulatory T cells has been identified in the brain, and the capacity of IL2-mediated expansion of this population to counter neuroinflammatory disease has been demonstrated. Here, we test a brain-specific IL2 delivery system for the prevention of neurological decline in aging mice. We identify the molecular hallmarks of aging in the brain glial co

SUBMITTER: Lemaitre P 

PROVIDER: S-EPMC10165365 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature