Matrix stiffness induces an invasive-dormant subpopulation via cGAS-STING axis in oral cancer.

ABSTRACT:

Objectives

Dormancy is a crucial machinery for cancer cells to survive hostile microenvironment. It is considered as the major cause of post-treatment relapse and metastases. However, its regulatory mechanism in oral squamous cell carcinoma (OSCC) remains unclear. Here we sought to decipher the impacts of matrix stiffness on OSCC-cell dormancy.

Materials and methods

Clinicopathological relevance of matrix stiffness in OSCC was analyzed in a 127 patients' cohort. Impacts of stiffness-related mechanical stress (MS) on OSCC-cell behaviors were investigated in vitro and in vivo. Transcriptomic profiling of MS induced dormant cells were performed, following by mechanistic investigations on MS-induced dormancy. The functional relevance of cGAS in OSCC were analyzed through a bioin

SUBMITTER: Jingyuan L 

PROVIDER: S-EPMC10165441 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature