Toxicity risk score and clinical decline after adjuvant chemotherapy in older breast cancer survivors.

ABSTRACT:

Background

Chemotoxicity risk scores were developed to predict grade 3-5 chemotherapy toxicity in older women with early breast cancer. However, whether these toxicity risk scores are associated with clinically meaningful decline in patient health remains unknown.

Methods

In a prospective study of women aged 65 years and older with stage I-III breast cancer treated with chemotherapy, we assessed chemotoxicity risk using the Cancer and Aging Research Group-Breast Cancer (CARG-BC) score (categorized as low, intermediate, and high). We measured patient health status before (T1) and after (T2) chemotherapy using a clinical frailty index (Deficit Accumulation Index, categorized as robust, prefrail, and frail). The population of interest was robust women at T1. The primary outcome

SUBMITTER: Ji J 

PROVIDER: S-EPMC10165485 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature