Multi-leveled Nanosilicate Implants Can Facilitate Near-Perfect Bone Healing.

ABSTRACT: Several studies have shown that nanosilicate-reinforced scaffolds are suitable for bone regeneration. However, hydrogels are inherently too soft for load-bearing bone defects of critical sizes, and hard scaffolds typically do not provide a suitable three-dimensional (3D) microenvironment for cells to thrive, grow, and differentiate naturally. In this study, we bypass these long-standing challenges by fabricating a cell-free multi-level implant consisting of a porous and hard bone-like framework capable of providing load-bearing support and a softer native-like phase that has been reinforced with nanosilicates. The system was tested with rat bone marrow mesenchymal stem cells in vitro and as a cell-free system in a critical-sized rat bone defect. Overall, our combinatorial and multi-level i

SUBMITTER: Keshavarz M 

PROVIDER: S-EPMC10165608 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature