Gut microbiome transitions across generations in different ethnicities in an urban setting-the HELIUS study.

ABSTRACT:

Background

During the course of history, various important lifestyle changes have caused profound transitions of the gut microbiome. These include the introduction of agriculture and animal husbandry, a shift from a nomadic to a more sedentary lifestyle, and recently increased levels of urbanization and a transition towards a more Western lifestyle. The latter is linked with shifts in the gut microbiome that have a reduced fermentative capability and which are commonly associated with diseases of affluence. In this study, in which 5193 subjects are included, we investigated the direction of microbiome shifts that occur in various ethnicities living in Amsterdam by comparing 1st and 2nd generation participants. We furthermore validated part of these findings with a cohort of subject

SUBMITTER: van der Vossen EWJ 

PROVIDER: S-EPMC10165778 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature