HDL-cholesterol concentration and its association with coronary artery calcification: a systematic review and meta-analysis.

ABSTRACT:

Background

Coronary artery calcification (CAC) is a potential risk marker of coronary atherosclerosis that has high specificity and sensitivity. However, the association between high-density lipoprotein cholesterol (HDL-C) concentration and CAC incidence and progression is controversial.

Methods

PubMed, Embase, Web of Science, and Scopus were systematically searched to identify relevant observational studies up to March 2023 and assessed the methodological quality using Newcastle-Ottawa Scale (NOS) scale. Random-effects meta-analysis was used to estimate pooled odds ratios (OR) and 95% confidence interval considering heterogeneity across studies.

Results

Of the 2,411 records, 25 cross-sectional (n = 71,190) and 13 cohort (n = 25,442) studies were included in the syste

SUBMITTER: Abedi F 

PROVIDER: S-EPMC10165789 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature