Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression.

ABSTRACT:

Background

Bronchial premalignant lesions (PMLs) are composed primarily of cells resembling basal epithelial cells of the airways, which through poorly understood mechanisms have the potential to progress to lung squamous cell carcinoma (LUSC). Despite ongoing efforts that have mapped gene expression and cell diversity across bronchial PML pathologies, signaling and transcriptional events driving malignancy are poorly understood. Evidence has suggested key roles for the Hippo pathway effectors YAP and TAZ and associated TEAD and TP63 transcription factor families in bronchial basal cell biology and LUSC. In this study we examine the functional association of YAP/TAZ, TEADs and TP63 in bronchial epithelial cells and PMLs.

Methods

We performed RNA-seq in primary human bronchia

SUBMITTER: Ning B 

PROVIDER: S-EPMC10165825 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature