The impact of timing of initiating invasive mechanical ventilation in COVID-19-related respiratory failure.

ABSTRACT:

Purpose

Optimal timing of initiating invasive mechanical ventilation (IMV) in coronavirus disease 2019 (COVID-19)-related respiratory failure is unclear. We hypothesized that a strategy of IMV as opposed to continuing high flow oxygen or non-invasive mechanical ventilation each day after reaching a high FiO2 threshold would be associated with worse in-hospital mortality.

Methods

Using data from Kaiser Permanente Northern/Southern California's 36 medical centers, we identified patients with COVID-19-related acute respiratory failure who reached ≥80% FiO2 on high flow nasal cannula or non-invasive ventilation. Exposure was IMV initiation each day after reaching high FiO2 threshold (T₀). We developed propensity scores with overlap weighting for receipt of IMV each da

SUBMITTER: Myers LC 

PROVIDER: S-EPMC10165890 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature