Diminished LAG3⁺ B cells correlate with exacerbated rheumatoid arthritis.

ABSTRACT:

Background

Lymphocyte activation gene-3 (LAG3) positive B cells have been identified as a novel regulatory B cell subset, while the role of LAG3⁺ B cells in the pathogenesis of rheumatoid arthritis (RA) remains elusive.

Materials and methods

Peripheral blood mononuclear cells (PBMCs) from RA, osteoarthritis (OA) patients and healthy volunteers were collected for flow cytometry staining of LAG3⁺ B cells. Their correlation with RA patient clinical and immunological features were analyzed. Moreover, the frequencies of LAG3⁺ B cells in collagen-induced arthritis (CIA) mice and naive mice were also detected.

Results

A significant decrease of LAG3⁺ B cells was observed in RA patients as compared with healthy individuals and OA pat

SUBMITTER: Hu S 

PROVIDER: S-EPMC10165927 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature