Tripeptides conjugated with thiosemicarbazones: new inhibitors of tyrosinase for cosmeceutical use.

ABSTRACT: The development of skin-care products is recently growing. Cosmetic formulas containing active ingredients with proven efficacy, namely cosmeceuticals, are based on various compounds, including peptides. Different whitening agents featuring anti-tyrosinase activity have been applied in the cosmeceutical field. Despite their availability, their applicability is often limited due to several drawbacks including toxicity, lack of stability, and other factors. In this work, we present the inhibitory effect on diphenolase activity of thiosemicarbazone (TSC)-peptide conjugates. Tripeptides FFY, FWY, and FYY were conjugated with three TSCs bearing one or two aromatic rings via amide bond formation in a solid phase. Compounds were then examined as tyrosinase and melanogenesis inhibitors in m

SUBMITTER: Ledwon P 

PROVIDER: S-EPMC10165932 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature