Estimating Potential Benefits to Neurocognition with Proton Therapy in Adults with Brain Tumors.

ABSTRACT:

Purpose

Photon radiation therapy (RT) is important in the treatment of many brain tumors but can negatively affect neurocognition. Proton therapy (PT) can reduce doses to normal brain structures. We compared photon and proton plans to estimate the potential benefit in cognition if the patient were treated with PT.

Materials and methods

We analyzed 23 adult patients with proton and photon plans for the treatment of a primary brain tumor. Cognitive outcomes were predicted using converted equivalent dose (EQD2) with an α/β ratio of 3 to left temporal lobe and normal brain tissue. Risks of cognitive decline on 2 specific tests, the Controlled Oral Word Association Test (COWAT [letter S], a test of verbal fluency) and the Wechler Adult Intelligence Scale (WAIS-IV Coding Test, a t

SUBMITTER: Petruccelli M 

PROVIDER: S-EPMC10166017 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature