Supporting Biomarker-Driven Therapies in Oncology: A Genomic Testing Cost Calculator.

ABSTRACT:

Background

Adoption of high-throughput, gene panel-based, next-generation sequencing (NGS) into routine cancer care is widely supported, but hampered by concerns about cost. To inform policies regarding genomic testing strategies, we propose a simple metric, cost per correctly identified patient (CCIP), that compares sequential single-gene testing (SGT) vs. multiplex NGS in different tumor types.

Materials and methods

A genomic testing cost calculator was developed based on clinically actionable genomic alterations identified in the European Society for Medical Oncology Scale for Clinical Actionability of molecular Targets. Using sensitivity/specificity data for SGTs (immunohistochemistry, polymerase chain reaction, and fluorescence in situ hybridization) and NGS and marker

SUBMITTER: Stenzinger A 

PROVIDER: S-EPMC10166172 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature