Comparing the functional neuroanatomy of proactive and reactive control between patients with schizophrenia and healthy controls.

ABSTRACT: Cognitive control deficits are associated with impaired executive functioning in schizophrenia. The Dual Mechanisms of Control framework suggests that proactive control requires sustained dorsolateral prefrontal activity, whereas reactive control marshals a larger network. However, primate studies suggest these processes are maintained by dual-encoding regions. To distinguish between these theories, we compared the distinctiveness of proactive and reactive control functional neuroanatomy. In a reanalysis of data from a previous study, 47 adults with schizophrenia and 56 controls completed the Dot Pattern Expectancy task during an fMRI scan examining proactive and reactive control in frontoparietal and medial temporal regions. Areas suggesting specialized control or between-group difference

SUBMITTER: Kwashie AN 

PROVIDER: S-EPMC10166198 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature