Fractional myocardial blood volume by ferumoxytol-enhanced MRI: Estimation of ischemic burden.

ABSTRACT:

Purpose

To investigate model-fitted fractional myocardial blood volume (fMBV) derived from ferumoxytol-enhanced MRI as a measure of myocardial tissue hypoperfusion at rest.

Methods

We artificially induced moderate to severe focal coronary stenosis in the left anterior descending artery of 19 swine by percutaneous delivery of a 3D-printed coronary implant. Using the MOLLI pulse sequence, we acquired T₁ maps at 3 T after multiple incremental ferumoxytol doses (0.0-4.0 mg/kg). We computed pixel-wise fMBV using a multi-compartmental modeling approach in 19 ischemic swine and 4 healthy swine.

Results

Ischemic myocardial segments showed a mean MRI-fMBV of 11.72 ± 3.00%, compared with 8.23 ± 2.12% in remote segments and 8.38 ± 2.23% in normal segments. Ischemic se

SUBMITTER: Colbert CM 

PROVIDER: S-EPMC10166270 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature