Safety and Acceptability of Three Ablation Treatments for High-Grade Cervical Precancer: Early Data From a Randomized Noninferiority Clinical Trial.

ABSTRACT:

Purpose

This ongoing trial is comparing the efficacy and safety of three ablation treatments for cervical intraepithelial neoplasia grade 2 or higher. Here, we present early data regarding pain, side effects, and acceptability of CO₂ gas-based cryotherapy (CO₂), nongas cryotherapy, and thermal ablation (TA). Efficacy results are expected to become available in late 2023.

Materials and methods

This noninferiority randomized trial is taking place in El Salvador, China, and Colombia. Patients are 1,152 eligible women with biopsy-confirmed cervical intraepithelial neoplasia grade 2 or higher who will receive one of three ablation treatments. Pain is measured before, during, and after treatment with a visual analog scale (1-10). Side effects and acceptabilit

SUBMITTER: Soler M 

PROVIDER: S-EPMC10166394 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature