Target Trial Emulation: A Design Tool for Cancer Clinical Trials.

ABSTRACT:

Purpose

To apply target trial emulation to explore the potential impact of eligibility criteria on the primary outcome of a randomized controlled trial.

Methods

Simulations of a real-world explanatory trial of transarterial radioembolization for advanced unresectable hepatocellular carcinoma with portal vein invasion were performed to examine the effects of cohort specification on survival outcomes and patient sample size. Simulations comprised 24 different permutations of the trial varied on three disease nonspecific eligibility parameters. Treatment and control arms for these emulated trials were drawn from the National Cancer Database and matched by treatment propensity. Target trial emulation served as the causal framework for this analysis, allowing the architecture of

SUBMITTER: Kwee SA 

PROVIDER: S-EPMC10166475 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature