Does adding MRI and CSF-based biomarkers improve cognitive status classification based on cognitive performance questionnaires?

ABSTRACT:

Background

Cognitive status classification (e.g. dementia, cognitive impairment without dementia, and normal) based on cognitive performance questionnaires has been widely used in population-based studies, providing insight into the population dynamics of dementia. However, researchers have raised concerns about the accuracy of cognitive assessments. MRI and CSF biomarkers may provide improved classification, but the potential improvement in classification in population-based studies is relatively unknown.

Methods

Data come from the Alzheimer's Disease Neuroimaging Initiative (ADNI). We examined whether the addition of MRI and CSF biomarkers improved cognitive status classification based on cognitive status questionnaires (MMSE). We estimated several multinomial logistic reg

SUBMITTER: Farina MP 

PROVIDER: S-EPMC10166486 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature