DFHiC: a dilated full convolution model to enhance the resolution of Hi-C data.

ABSTRACT:

Motivation

Hi-C technology has been the most widely used chromosome conformation capture (3C) experiment that measures the frequency of all paired interactions in the entire genome, which is a powerful tool for studying the 3D structure of the genome. The fineness of the constructed genome structure depends on the resolution of Hi-C data. However, due to the fact that high-resolution Hi-C data require deep sequencing and thus high experimental cost, most available Hi-C data are in low-resolution. Hence, it is essential to enhance the quality of Hi-C data by developing the effective computational methods.

Results

In this work, we propose a novel method, so-called DFHiC, which generates the high-resolution Hi-C matrix from the low-resolution Hi-C matrix in the framework of the

SUBMITTER: Wang B 

PROVIDER: S-EPMC10166584 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature