Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis.

ABSTRACT:

Background

Childhood obesity is a global health concern and can lead to lifetime cardiometabolic disease. New advances in metabolomics can provide biochemical insights into the early development of obesity, so we aimed to characterize serum metabolites associated with overweight and adiposity in early childhood and to stratify associations by sex.

Methods

Nontargeted metabolite profiling was conducted in the Canadian CHILD birth cohort (discovery cohort) at age 5 years (n = 900) by multisegment injection-capillary electrophoresis-mass spectrometry. Clinical outcome was defined using novel combined measures of overweight (WHO-standardized body mass index ≥ 85th percentile) and/or adiposity (waist circumference ≥ 90th percentile). Associations between circulating metabolites a

SUBMITTER: Azab SM 

PROVIDER: S-EPMC10166631 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature