Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis.

ABSTRACT:

Aim

 This study aimed to evaluate the effectiveness of melatonin in treating insomnia in children with autism spectrum disorder (ASD).

Methods

 Comprehensive searches were conducted in the PubMed, EMBASE, and Web of Science databases from their inception to April 20, 2022. Data were extracted and assessed for quality by two researchers. Statistical analysis was performed using the Stata 15.0 software.

Results

 Four studies including 238 patients were included. The results showed that compared with the control group, melatonin could shorten the sleep-onset latency (standardized mean difference [SMD] = - 1.34, 95% CI: -2.19 to -0.48), reduce the number of awakenings (SMD = -2.35, 95% CI: -4.62 to -0.08), and prolong the total sleep time (SMD = 1.42, 95% CI: 0.5-2.33) in

SUBMITTER: Xiong M 

PROVIDER: S-EPMC10166641 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature