The landscape of neurophysiological outcome measures in ALS interventional trials: A systematic review.

ABSTRACT:

Objective

We collated all interventional clinical trials in amyotrophic lateral sclerosis (ALS), which utilised at least one neurophysiological technique as a primary or secondary outcome measure. By identifying the strengths and limitations of these studies, we aim to guide study design in future trials.

Methods

We conducted and reported this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eight databases were searched from inception. In total, 703 studies were retrieved for screening and eligibility assessment.

Results

Dating back to 1986, 32 eligible interventional clinical trials were identified, recruiting a median of 30 patients per completed trial. The most widely employed neurophysiological tech

SUBMITTER: Ahmed N 

PROVIDER: S-EPMC10166714 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature