Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain.

ABSTRACT: Pain is a persistent symptom of Rheumatoid Arthritis, and the K/BxN serum transfer model recapitulates both association and dissociation between pain and joint inflammation in RA. Furthermore, this model features monocyte/macrophage infiltration in joints and lumbar dorsal root ganglia (DRG), where these immune cells are close to nociceptive neurons. We focussed on CX₃CR₁-monocyte/macrophage trafficking and show that at peak paw swelling associated with nociception, CX₃CR₁ deletion altered neither swelling nor macrophage infiltration/phenotype in paws. However, acute nociception and DRG non-classical monocyte numbers were reduced in CX₃CR₁^GFP/GFP (KO) compared to CX₃CR₁^+/GFP (WT).

SUBMITTER: Oggero S 

PROVIDER: S-EPMC10166715 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature