Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease.

ABSTRACT:

Introduction

Blood-based diagnostics and prognostics in sporadic Alzheimer's disease (AD) are important for identifying at-risk individuals for therapeutic interventions.

Methods

In three stages, a total of 34 leukocyte antigens were examined by flow cytometry immunophenotyping. Data were analyzed by logistic regression and receiver operating characteristic (ROC) analyses.

Results

We identified leukocyte markers differentially expressed in the patients with AD. Pathway analysis revealed a complex network involving upregulation of complement inhibition and downregulation of cargo receptor activity and Aβ clearance. A proposed panel including four leukocyte markers - CD11c, CD59, CD91, and CD163 - predicts patients' PET Aβ status with an area under the curve (AUC) of 0.

SUBMITTER: Huang X 

PROVIDER: S-EPMC10166765 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature