Developmental trajectories of premorbid functioning predict cognitive remediation treatment response in first-episode schizophrenia.

ABSTRACT:

Background

Cognitive development after schizophrenia onset can be shaped by interventions such as cognitive remediation, yet no study to date has investigated whether patterns of early behavioral development may predict later cognitive changes following intervention. We therefore investigated the extent to which premorbid adjustment trajectories predict cognitive remediation gains in schizophrenia.

Methods

In a total sample of 215 participants (170 first-episode schizophrenia participants and 45 controls), we classified premorbid functioning trajectories from childhood through late adolescence using the Cannon-Spoor Premorbid Adjustment Scale. For the 62 schizophrenia participants who underwent 6 months of computer-assisted, bottom-up cognitive remediation interventions, we

SUBMITTER: Kuo SS 

PROVIDER: S-EPMC10166766 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature