Genetically and environmentally predicted obesity in relation to cardiovascular disease: a nationwide cohort study.

ABSTRACT:

Background

Evidence indicates that the adverse health effects of obesity differ between genetically and environmentally influenced obesity. We examined differences in the association between obesity and cardiovascular disease (CVD) between individuals with a genetically predicted low, medium, or high body mass index (BMI).

Methods

We used cohort data from Swedish twins born before 1959 who had BMI measured between the ages of 40-64 years (midlife) or at the age of 65 years or later (late-life), or both, and prospective CVD information from nationwide register linkage through 2016. A polygenic score for BMI (PGS_BMI) was used to define genetically predicted BMI. Individuals missing BMI or covariate data, or diagnosed with CVD at first BMI measure, were excluded, lea

SUBMITTER: Ojalehto E 

PROVIDER: S-EPMC10166783 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature