Opposing regulation of the Nα-trimethylase METTL11A by its family members METTL11B and METTL13.

ABSTRACT: N-terminal protein methylation (Nα-methylation) is a posttranslational modification that influences numerous biological processes by regulating protein stability, protein-DNA interactions, and protein-protein interactions. Although significant progress has been made in understanding the biological roles of Nα-methylation, we still do not completely understand how the modifying methyltransferases are regulated. A common mode of methyltransferase regulation is through complex formation with close family members, and we have previously shown that the Nα-trimethylase METTL11A (NRMT1/NTMT1) is activated through binding of its close homolog METTL11B (NRMT2/NTMT2). Other recent reports indicate that METTL11A co-fractionates with a third METTL family member METTL13, which methylates both the N-ter

SUBMITTER: Parker HV 

PROVIDER: S-EPMC10166787 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature