PM10 promotes an inflammatory cytokine response that may impact SARS-CoV-2 replication in vitro.

ABSTRACT:

Introduction

In the last decades, a decrease in air quality has been observed, mainly associated with anthropogenic activities. Air pollutants, including particulate matter (PM), have been associated with adverse effects on human health, such as exacerbation of respiratory diseases and infections. High levels of PM in the air have recently been associated with increased morbidity and mortality of COVID-19 in some regions of the world.

Objective

To evaluate the effect of coarse particulate matter (PM10) on the inflammatory response and viral replication triggered by SARS-CoV-2 using in vitro models.

Methods

Peripheral blood mononuclear cells (PBMC) from healthy donors were treated with PM10 and subsequently exposed to SARS-CoV-2 (D614G strain, MOI 0.1). The prod

SUBMITTER: Marin-Palma D 

PROVIDER: S-EPMC10166799 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature