Landscapes and mechanisms of CD8⁺ T cell exhaustion in gastrointestinal cancer.

ABSTRACT: CD8⁺ T cells, a cytotoxic T lymphocyte, are a key component of the tumor immune system, but they enter a hyporeactive T cell state in long-term chronic inflammation, and how to rescue this depleted state is a key direction of research. Current studies on CD8⁺ T cell exhaustion have found that the mechanisms responsible for their heterogeneity and differential kinetics may be closely related to transcription factors and epigenetic regulation, which may serve as biomarkers and potential immunotherapeutic targets to guide treatment. Although the importance of T cell exhaustion in tumor immunotherapy cannot be overstated, studies have pointed out that gastric cancer tissues have a better anti-tumor T cell composition compared to other cancer tissues, which may indicate th

SUBMITTER: Ding JT 

PROVIDER: S-EPMC10166832 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature