Immunocytoprotection after reperfusion with Kv1.3 inhibitors has an extended treatment window for ischemic stroke.

ABSTRACT: Introduction: Mechanical thrombectomy has improved treatment options and outcomes for acute ischemic stroke with large artery occlusion. However, as the time window of endovascular thrombectomy is extended there is an increasing need to develop immunocytoprotective therapies that can reduce inflammation in the penumbra and prevent reperfusion injury. We previously demonstrated, that by reducing neuroinflammation, K_V1.3 inhibitors can improve outcomes not only in young male rodents but also in female and aged animals. To further explore the therapeutic potential of K_V1.3 inhibitors for stroke therapy, we here directly compared a peptidic and a small molecule K_V1.3 blocker and asked whether K_V1.3 inhibition would still be beneficial when sta

SUBMITTER: Lee RD 

PROVIDER: S-EPMC10166874 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature