Response to induction chemotherapy predicts survival outcomes in oropharyngeal cancer.

ABSTRACT:

Background

The role of induction chemotherapy (IC) in oropharyngeal squamous cell carcinoma (OPSCC) remains controversial. Its interpretation can be confounded by heterogeneity in chemosensitivity and human papillomavirus (HPV) status. This study aimed to investigate the prognostic impact of IC response in HPV-positive and -negative OPSCC.

Methods

Patients with OPSCC who underwent IC and concurrent chemoradiotherapy (CCRT) were retrospectively analyzed. Radiologic response to IC by ≥50% was defined as IC-sensitive (IC-s), while lesser response was deemed as IC-resistant (IC-r). Progression-free survival (PFS) and overall survival (OS) were compared between subgroups.

Results

A total of 51 HPV-positive and 57 HPV-negative patients were included. IC-s patients accounted

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC10166893 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature