Comprehensive transcriptomic analysis to identify biological and clinical differences in cholangiocarcinoma.

ABSTRACT:

Background

Cholangiocarcinoma (CC) is a rare and aggressive disease with limited therapeutic options and a poor prognosis. All available public records of cohorts reporting transcriptomic data on intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) were collected with the aim to provide a comprehensive gene expression-based classification with clinical relevance.

Methods

A total of 543 patients with primary tumor tissues profiled by RNAseq and microarray platforms from seven public datasets were used as a discovery set to identify distinct biological subgroups. Group predictors developed on the discovery sets were applied to a single cohort of 131 patients profiled with RNAseq for validation and assessment of clinical relevance leveraging machine l

SUBMITTER: Silvestri M 

PROVIDER: S-EPMC10166943 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature