Optimal starting age of endoscopic screening for esophageal cancer in China: A multicenter prospective cohort study.

ABSTRACT: Although endoscopic screening for esophageal cancer has been performed in high-risk areas in China for decades, there is limited and inconsistent evidence regarding the starting age for individuals participating in screening. The aim of this study is to investigate the optimal starting age of esophageal cancer screening. This study is based on a multicenter prospective cohort consisting 338,017 permanent residents aged 40-69 years in six high-risk areas of esophageal cancer in China. The participation rate, detection rate, hazard ratios (HRs), cumulative incidence and mortality and number needed to screen (NNS) were calculated in each age group. Screening burden, benefit and risk were compared among screening strategies with different initiation ages to explore the optimal starting age for

SUBMITTER: Chen R 

PROVIDER: S-EPMC10166951 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature