Hypoxia-induced YAP activation and focal adhesion turnover to promote cell migration in mesenchymal TNBC cells.

ABSTRACT:

Background

Hypoxia is commonly characterized by malignant tumors that promote the aggressiveness and metastatic potential of cancer. Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with approximately 46% capacity related to distant metastasis. Transcriptional factor yes-associated protein (YAP), a core component of the Hippo pathway, is associated with poor prognosis and outcome in cancer metastasis. Here, we explored the effect of hypoxia-mediated YAP activation and focal adhesions (FAs) turnover in mesenchymal TNBC cell migration.

Methods

We characterized the effect of hypoxia on YAP in different breast cancer cell lines using a hypoxia chamber and CoCl₂ .

Results

Hypoxia-induced YAP nuclear translocation is significa

SUBMITTER: Nguyen TMH 

PROVIDER: S-EPMC10166962 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature