Combined all-trans retinoic acid with low-dose apatinib in treatment of recurrent/metastatic head and neck adenoid cystic carcinoma: A single-center, secondary analysis of a phase II study.

ABSTRACT:

Background

Treatment options are limited for recurrent/metastatic adenoid cystic carcinoma of the head and neck (R/M ACCHN). We aimed to evaluate the preliminary results of the efficacy and safety of all-trans retinoic acid (ATRA) combined with low-dose apatinib in patients with R/M ACCHN according to a secondary analysis of a phase II study.

Methods

Patients from a phase II study (NCT02775370) who orally administered 500 milligram (mg) apatinib daily until treatment-related adverse events (AEs) intolerance or progression occurred were eligible for inclusion. Patients were further treated with combination therapy of ATRA (25 mg/m² /day) and apatinib (250 mg/day) between March 2019 and October 2021 until progression of disease (PD).

Results

A total of 16 pat

SUBMITTER: Ye L 

PROVIDER: S-EPMC10166967 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature